Symbol
Name
ID

Il21r
interleukin 21 receptor
MGI:1890475

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Decreased circulating antibody level

Panhypogammaglobulinemia

Epistaxis

Purpura

Hemolytic anemia

Lymphopenia

Leukopenia

Arterial thrombosis

Superficial thrombophlebitis

Abnormality of thrombocytes

Thrombocytopenia

Autoimmune thrombocytopenia

Lymphoma

Elevated erythrocyte sedimentation rate

Splenomegaly

Disease(s) Associated with IL21R

Behcet's disease

common variable immunodeficiency

immunodeficiency 56

systemic lupus erythematosus

temporal arteritis

Mouse Phenotypes

decreased T cell proliferation

abnormal thymocyte activation

abnormal CD4-positive T cell differentiation

decreased basophil cell number

decreased eosinophil cell number

decreased granulocyte number

decreased CD4-positive, alpha-beta T cell number

abnormal leukocyte physiology

impaired eosinophil recruitment

abnormal lymphocyte physiology

abnormal immunoglobulin level

decreased IgA level

decreased IgE level

increased IgE level

decreased IgG1 level

decreased IgG2a level

decreased IgG2b level

decreased IgG3 level

abnormal NK cell physiology

impaired natural killer cell mediated cytotoxicity

abnormal T cell physiology

abnormal T-helper 1 physiology

abnormal T-helper 2 physiology

abnormal CD8-positive, alpha-beta T cell physiology

decreased cytotoxic T cell cytolysis

abnormal T cell activation

abnormal memory T cell physiology

Availability

Mouse Genotype

Il21r^tm1Day/Il21r^tm1Day

Il21r^tm1Kopf/Il21r^tm1Kopf

Il21r^tm1Wjl/Il21r^tm1Wjl

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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